Serperior is a pretty decent Support to use for single battles. With Overgrow, at 1/3 or less of its max hp Serperior's offensive stat is 1.5x with grass attacks. With good defenses and speed, Serperior is a great candidate for Calm Mind, needing very little help to set up. After one or two Calm Minds, Serperior's offensive abilities improve significantly, and enable it to bring down most Pokemon with a Giga Drain or Hidden Power. After a Calm Mind, Serperior's Special Attack will only be as high as a neutral natured Jellicent's, so getting off more than one Calm Mind should be your goal, and is safer when Serperior has Rest and Chesto Berry. With a Chesto Berry equipped to it, Serperior wakes up if it is asleep then the Chesto Berry gets consumed.

Serperior shows popular Physical Tank prowess in single battles. The intention of this moveset is to absorb physical damage and return fire with decent force. With Contrary, if Serperior has a stat stage raised it is lowered instead and vice versa. With a Zoom Lens equipped to it, the accuracy of attacks by Serperior is 1.2x if it moves after its target.

For those intense single battles, Serperior is a spectacular Double Wall. This moveset was constructed to balance defenses for both physical and special attacks. With Overgrow, at 1/3 or less of its max hp Serperior's offensive stat is 1.5x with grass attacks. This Moveset is a tricky one. I can't decide for its Nature though. First is to set Leech seed + Growth combo. Once Special attack increased, use Giga Drain and your HP will be boosted to Full then use Wring Out another Special Attack to achieve its maximum damage dealt which is 120. This is a no TM and no Breeding moveset so any can replace Growth with Calm Mind though. With a Big Root equipped to it, Serperior gains 1.3x hp from draining moves, aqua ring, ingrain, and leech seed.